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A simple force-motion relationship of migrating cells
In this talk, we would discuss about a force-motion relationship of migrating eukaryotic adherent cells. Biological cells migrate without net forces, which is a consequence of force-free and negligible inertia conditions (Purcell, 1977). This indicates that to elucidate a force-motion relationship, unlike in cases governed by Newton’s law, we must focus on the spatial pattern of the force field instead of just its summation. We measured the traction stress of migrating Dicyostelium cells and quantified its spatial property via multi-pole expansion. Investigating the lowest two moments force dipole and quadrupole, we derived a simple force-motion relationship in which cells migrate along the force dipole axis with a direction determined by the force quadrupole. I would show this result in this talk and discuss about the mechanisms of cell motility underlying this force-motion relationship.
If we have more time, I would also show some results of the same force measurement of dividing cells.
Informations contextuelles :
Séminaire du laboratoire Gulliver
Contact : mathilde.reyssat@espci.fr